拉帕替尼(lapatinib)病人用藥信息

導讀：乳腺癌是一種嚴重影響婦女身心健康甚至危及生命的最常見的惡性腫瘤之一，男性也會發生乳腺癌。乳腺癌常用治療方法有手術、放化療、內分泌治療、中醫藥治療相結合的綜合治療方式。目前，分子靶向治療也通入常規治療范疇。乳腺癌的發病日趨年輕化，發病率有上升趨勢，年輕女性要重視自己的乳房健康。了解和掌握防癌知識，認真做好自我檢查，定期體檢是防治乳腺癌的有效手段。如早發現、早治療，約90%乳腺癌患者可達治愈。

藥物治療——乳腺癌


拉帕替尼(lapatinib)患者用藥信息 PATIENT INFORMATION FDA-Approved Patient Labeling
TYKERB® (TIE-curb)
(lapatinib) tablets
Read this leaflet before you start taking TYKERB and each time you get a refill. There may be new information. This information does not take the place of talking with your doctor about your medical condition or treatment.
What is TYKERB?
TYKERB is used with the medicine capecitabine for the treatment of patients with advanced or metastatic breast cancer that is HER2 positive, and who have already had certain other breast cancer treatments.
Before you start taking TYKERB, tell your doctor about all of your medical conditions, including if you: have heart problems. have liver problems. You may need a lower dose of TYKERB. are pregnant or may become pregnant. TYKERB may harm an unborn baby. If you become pregnant during treatment with TYKERB, tell your doctor as soon as possible. are breastfeeding. It is not known if TYKERB passes into your breast milk or if it can harm your baby. If you are a woman who has or will have a baby, talk with your doctor about the best way to feed your baby.
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines and herbal and dietary supplements. TYKERB and many other medicines may interact with each other. Your doctor needs to know what medicines you take so he or she can choose the right dose of TYKERB for you.
Especially tell your doctor if you take: antibiotics and anti-fungals (drugs used to treat infections) HIV (AIDS) treatments anticonvulsant drugs (drugs used to treat seizures) calcium channel blockers (drugs used to treat certain heart disorders or high blood pressure) antidepressants drugs used for stomach ulcers St. John's Wort or other herbal supplements
Know the medicines you take. Keep a list of your medicines with you to show your doctor. Do not take other medicines during treatment with TYKERB without first checking with your doctor.
Because TYKERB is given with another drug called capecitabine, you should also discuss with your doctor or pharmacist any medicines that should be avoided when taking capecitabine.
How should I take TYKERB? Take TYKERB exactly as your doctor has told you. TYKERB and capecitabine are taken in 21 day cycles. The usual dose of TYKERB is 1,250 mg (5 tablets) taken by mouth, one time a day on days 1 to 21. Your doctor will tell you the dose of capecitabine you should take and when you should take it. TYKERB should be taken at least one hour before, or at least one hour after food. Do not eat or drink grapefruit products while taking TYKERB. Your doctor may adjust your dose of TYKERB depending on how you tolerate the treatment. If you forget to take your dose of TYKERB, take it as soon as you remember that day. If you miss a day, do not double your dose the next day. Just skip the missed dose.
What are the possible side effects of TYKERB?
Serious side effects include: heart problems decreased pumping of blood from the heart abnormal heartbeat lung problems severe diarrhea, which may lead to you becoming dehydrated
Call your doctor right away if you have palpitations, persistent cough, shortness of breath, or severe diarrhea.
Common side effects of TYKERB in combination with capecitabine include: diarrhea red, painful hands and feet nausea rash vomiting tiredness mouth sores loss of appetite indigestion
Tell your doctor about any side effect that gets serious or that does not go away.
These are not all the side effects with TYKERB. Ask your doctor or pharmacist for more information.
You may also get side effects from capecitabine. Talk to your doctor about possible side effects with capecitabine.
How should I store TYKERB tablets? Store TYKERB tablets at room temperature between 59° and 86°F (15° to 30°C). Keep the container closed tightly. Do not keep medicine that is out of date or that you no longer need. Be sure that if you throw any medicine away, it is out of the reach of children. Keep TYKERB and all medicines out of the reach of children.
General information about TYKERB
Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use TYKERB for any other condition for which it was not prescribed. Do not give TYKERB to other people, even if they have the same condition that you have. It may harm them.
This leaflet summarizes the most important information about TYKERB. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about TYKERB that is written for health professionals. For more information you can call toll-free 1-888-825-5249.
What are the ingredients in TYKERB?
Active Ingredient: Lapatinib.
Inactive Ingredients: Tablet Core: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate. Coating: Orange film-coat: FD&C yellow #6/sunset yellow FCF aluminum lake, hypromellose, macrogol/PEG 400, polysorbate 80, titanium dioxide.TYKERB tablets are oval, biconvex, orange, film-coated with GS XJG printed on one side.
 
參考文獻（略）

　　百濟新特連鎖藥業是一家經營和管理重大慢性疾病用藥的連鎖專科藥房，同時也是全國最大的專科醫藥連鎖企業。藥房擁有400多種腫瘤類藥品，囊括肺癌、肝癌、胃癌、前列腺癌、乳腺癌、結直腸癌等主流新特藥品，專業的網站為您提供腫瘤相關信息，包括腫瘤癥狀，腫瘤的治療以及腫瘤患者的生活調理等。客服中心由數十位資深藥師組成，依托400免費電話，以科學客觀的態度介紹藥品，為全國顧客提供更便捷、更專業的藥品咨詢服務。

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